What is the meaning of adenosine deaminase?

What is the meaning of adenosine deaminase?

Medical Definition of adenosine deaminase : an enzyme which catalyzes the conversion of adenosine to inosine and whose deficiency causes a form of severe combined immunodeficiency disease as a result of the accumulation of toxic metabolites which inhibit DNA synthesis —abbreviation ADA.

Which drug inhibit adenosine deaminase enzyme?

Pentostatin, EHNA, and 1-deazaadenosine are known ADA inhibitors. It has been demonstrated that EHNA specifically inhibits ADA1, while pentostatin and 1-deazaadenosine can inhibit both ADA1 and ADA2 (Ratech et al.

What type of enzyme is adenosine deaminase?

Adenosine deaminase (ADA) is an enzyme of the purine metabolism which catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. This ubiquitous enzyme has been found in a wide variety of microorganisms, plants, and invertebrates.

How is adenosine deaminase regulated?

The primary mechanism for the control of this ubiquitous enzyme is at the level of transcription. Our results demonstrate that p73 modulates ADA expression in response to the enzyme deficit through a feedback regulation mechanism.

How does ADA deficiency cause SCID?

Adenosine deaminase deficiency (ADA deficiency) is an inherited condition that damages the immune system and is a common cause of severe combined immunodeficiency (SCID). People with SCID due to ADA deficiency are unable to fight off most types of infections, including bacterial, viral and fungal infections.

What is ADA level?

Pleural fluid ADA level was more than 36 IU/L in cases of tubercular pleural effusion. It ranged 36 to 229.7 IU/L. While in case of malignancy it was more than 18.5 IU/L (18.5 to 87.6 IU/L). In one case of hypoproteinemia it was 9.21 IU/L.

What happens if ADA is high?

what do the adenosine deaminase test results mean? If the Adenosine Deaminase level in one’s pleural fluid is much higher then the ADA normal range, the result is usually indicative of Mycobacterium tuberculosis infection in their pleurae.

What causes ADA deficiency?

ADA deficiency is caused by mutations in the ADA gene and is inherited in an autosomal recessive manner. Diagnosis may be suspected by newborn screening or symptoms and confirmed by blood and genetic test results.

What is the function of enzyme adenosine deaminase?

The function of the adenosine deaminase enzyme is to eliminate a molecule called deoxyadenosine, which is generated when DNA is broken down. Adenosine deaminase converts deoxyadenosine, which is toxic to lymphocytes, to another molecule called deoxyinosine, which is not harmful.

Why is ADA High in TB?

Adenosine deaminase (ADA) has been developed and widely used for the diagnosis of TB. ADA is an enzyme that increases in TB because of the stimulation of T-cell lymphocytes by mycobacterial antigens.

Is adenosine deaminase a protein?

From a metabolic point of view, adenosine deaminase (ADA) is an essential protein in the regulation of the total intracellular and extracellular adenosine in a tissue. In addition to its cytosolic localization, ADA is also expressed as an ecto-enzyme on the surface of different cells.

What is ADA deficiency?

Adenosine deaminase (ADA) deficiency is an inherited disorder that damages the immune system and causes severe combined immunodeficiency (SCID). People with SCID lack virtually all immune protection from bacteria, viruses, and fungi.