What is P MAPK?

What is P MAPK?

Introduction. The Human Phospho-Mitogen-activated Protein Kinase (MAPK) Antibody Array (Catalog # ARY002B) is an economical tool used to simultaneously detect the relative phosphorylation of 24 kinases without performing numerous immunoprecipitation and/or Western blots.

What is the molecular weight of MAPK?

Other Names p42/44 MAPK SAPK1
Molecular Weight (kDa) 42 – 44 kDa 48 – 52 kDa
Isoforms ERK1 ERK2 (M3172, M9426) JNK1 JNK2 JNK3
Species Eukaryotes C. elegans Drosophila vertebrates
Domain Organization 1 kinase domain 1 kinase domain

What is P ERK1 2?

Extracellular signal-related kinase (ERK1/2 or p42/44) is a serine/threonine kinase that acts as an essential component of the Mitogen-Activated Protein Kinase (MAPK) signal transduction pathway.

What is p44 p42?

The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines (1-3), and research investigators consider it an important target in the diagnosis and treatment of cancer (4).

What does ERK1 stand for?

Abstract. The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is a central signaling pathway that regulates a wide variety of stimulated cellular processes, including mainly proliferation, differentiation, and survival, but apoptosis and stress response as well.

What is the significance of ERK1/2 signaling in cancer biology?

The significance of the ERK1/2 signaling in cancer biology was first identified when Ras proteins were found as the transforming component of oncogenic viruses for K-Ras and H-Ras, whereas N-Ras was identified as the transforming component of a neuroblastoma 130; 131.

How do extracellular signal-regulated protein kinases 1 and 2 mediate cell death?

Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-activated protein kinase super family that can mediate cell proliferation and apoptosis. The Ras–Raf–MEK–ERK signaling cascade controlling cell proliferation has been well studied but the mechanisms involved in ERK1/2-mediated cell death are largely unknown.

What is the role of phosphorylation of the MAP kinase ERK2?

Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell. 1998;93:605–615. [PubMed] [Google Scholar]

What is the role of the ERK1/2 signaling pathway in BIM degradation?

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. The Journal of biological chemistry. 2003;278:18811–18816. [PubMed] [Google Scholar] 84. Ley R, Ewings KE, Hadfield K, Howes E, Balmanno K, Cook SJ.