What is genotype in HCV?
Genotypes of HCV are genetically distinct groups of the virus that have arisen during its evolution.(1) Approximately 75% of Americans with HCV have genotype 1 of the virus (subtypes 1a or 1b), and 20-25% have genotypes 2 or 3, with small numbers of patients infected with genotypes 4, 5, or 6.(2) Most patients with HCV …
Which HCV genotype is most common?
HCV subtypes 1a and 1b are the most common genotypes in the United States (Fig. 3) (145). These subtypes also are predominant in Europe (35, 82, 91).
Which HCV genotype is easiest to treat?
- In the DAA era, HCV genotype 3 has emerged as the most difficult HCV genotype to treat.
- For treatment-naïve adults without cirrhosis, two regimens are recommended with equal evidence rating: (1) glecaprevir-pibrentasvir for 8 weeks, or (2) sofosbuvir-velpatasvir for 12 weeks.
What is HCV genotype 3a?
Genotype 3 represents a unique entity within HCV treatment. It is associated with genotype specific mechanisms of steatosis in addition to accelerated development of fibrosis and higher rates of hepatocellular carcinoma. These findings underscore the need for effective therapy for this group of patients.
What does genotype 4 mean?
Abstract. Hepatitis C virus genotype 4 (HCV-4) is the most common variant of the hepatitis C virus (HCV) in the Middle East and Africa, particularly Egypt. This region has the highest prevelance of HCV worldwide, with more than 90% of infections due to genotype 4.
Can HCV genotype change?
Six major genotypes of the hepatitis C virus (HCV) have been described; it is assumed to be uncommon for genotypes to change in chronically infected individuals.
Why is HCV genotype important?
Knowing your HCV genotype is important information that can help patients and doctors find the most effective treatment. All HCV genotypes cause the same amount of liver damage.
How long can you live with Hep C genotype 3?
Results. A total of 180 patients were enrolled. Of these, 86, 78, and 16 had genotype 1, genotype 2, and genotype 3 HCV-related HCC, respectively. The median age was 66.0 years, and the median overall survival was 28.6 months.
Is Hep 3 curable?
Treatment typically lasts between 8 and 24 weeks and includes combinations of antiviral drugs that attack the virus. These treatments can help minimize or prevent liver damage.
What’s the most common genotype?
Hepatitis C virus genotype 1 is the most prevalent genotype and accounts for 83.4 million infections, or 46.2% of all cases, worldwide, according to a study published in Hepatology.
How is the genotype of hepatitis C virus (HCV) determined?
An important variable for all patients with chronic hepatitis C virus (HCV) is the “genotype” of HCV with which they are infected. This is the strain of the virus to which they were exposed when they were infected, often many years prior to their evaluation, and it is determined by a simple blood test.
Is hepatitis C virus (HCV) a flavivirus?
As the HCV genome is similar to flavivirus in structure and phenotypic characteristics, flavivirus is classified as HCV in the Hepacivirus genus of Flaviviridae family [155,156]. IFNα combined with ribavirin is also the standard regimen (SOC) for the treatment of chronic hepatitis C approved by EASL.
What is the genome of Flavivirus?
The Flaviviridae family comprises a large group of enveloped viruses with a single-strand RNA genome of positive polarity. The genome of flavivirus encodes ten proteins, and each of them plays a different and important role in viral infection.
Does genotype affect liver disease progression due to hepatocellular virus (HCV)?
Genotype generally has not been found in epidemiological studies to play a large role in liver disease progression due to HCV. Rather, genotype is of clinical importance principally as a factor in selecting the appropriate HCV medications for treatment. Please see the HCV Treatment Considerations