What is GATA3 a marker for?

What is GATA3 a marker for?

GATA3 is a useful marker in characterization not only mammary and urothelial but also for renal and germ cell tumors, mesotheliomas, and paragangliomas. The multiple specificities of GATA3 should be taken into account when using this marker to detect metastatic mammary or urothelial carcinomas.

What does GATA3 stand for?

GATA3 (GATA binding protein 3)

What is GATA3 gene?

GATA3 (GATA Binding Protein 3) is a Protein Coding gene. Diseases associated with GATA3 include Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome and Hypoparathyroidism-Deafness-Renal Disease Syndrome. Among its related pathways are G-AlphaQ Signaling and Interleukin-4 and 13 signaling.

Where is GATA3 found?

The location of GATA3 borders that of other critical sites on chromosome 10, particularly a site located at 10p14-p13. Mutations in this site cause the congenital disorder DiGeorge syndrome/velocardiofacial syndrome complex 2 (or DiGeorge syndrome 2).

Which cells express GATA3?

GATA3 is expressed by all ILCs including lymphoid tissue inducer (LTi) cells and natural killer (NK) cells, albeit at different levels. GATA3 is required for the development of IL-7Rα-expressing ILCs but not NK cells as shown in Figure 1.

What regulates GATA3?

(A) GATA3 is regulated by multiple upstream signals. Signaling cascades activated through IL-4R, IL-2R, TCR, Notch and Frizzled (receptor for Wnt) lead to activation of GATA3. p38 phosphorylates GATA3 to promote its nuclear translocation. GATA3 also activates its own expression through a feedback loop.

What does negative for GATA3 mean?

The GATA3 positivity cutoff value was determined to be 4%, which was the median value of all STS cases in this study. Cases with a value > 4% were defined as GATA3-positive cases, while those with a value ≤ 4% were defined as GATA3-negative cases.

What is GATA3 negative?

GATA3 negative tumors were enriched in the basal-like molecular subgroup and were associated with negative estrogen receptor (ER) and negative progesterone receptor (PR) statuses. Both CK7 and GATA3 expression showed no association with overall survival in patients with Grade 3 tumor.

What is GATA3 marker used for?

GATA3 is a useful marker in the characterization of not only mammary and urothelial but also renal and germ cell tumors, mesotheliomas, and paragangliomas. The multiple specificities of GATA3 should be taken into account when using this marker to detect metastatic mammary or urothelial carcinomas.

Is GATA-binding protein 3 a marker for Primary genital Extramammary Paget diseases?

[…] GATA-binding protein 3 (GATA3) has been identified as a sensitive marker for breast carcinoma but its sensitivity in primary genital extramammary Paget diseases (EMPDs) has not been well studied.

What is GATA 3?

GATA 3 – A MULTISPECIFIC BUT POTENTIALLY USEFUL MARKER IN SURGICAL PATHOLOGY – A SYSTEMATIC ANALYSIS OF 2500 EPITHELIAL AND NON-EPITHELIAL TUMORS

What is the prognosis of GATA binding protein 3 (Gata) toxicity in bladder cancer?

Miyamoto H, Izumi K, Yao JL, et al. GATA binding protein 3 is down-regulated in bladder cancer yet strong expression is an independent predictor of poor prognosis in invasive tumor. Hum Pathol. 2012;43:2033–2040.