What is fundus flavimaculatus?
Fundus flavimaculatus (FFM) is a Stargardt-like condition that is later-onset and slow-progressing. FFM presents with white or yellowish-white pisciform flecks possibly with foveal atrophy. While no treatment is available, studies are investigating novel treatment options.
What are retinal flecks?
The term “flecked retina” was introduced by Krill and Klien to describe fundus conditions characterized by multiple yellowish-white lesions of various size and configuration, without vascular or optic nerve abnormalities.
Can fundus flavimaculatus cause blindness?
(In the United States, legal blindness is defined as visual acuity of 20/200 or worse while wearing corrective lenses.) Those who have the fundus flavimaculatus form of the disease, however, are likely to experience even more severe vision loss.
What does Vitelliform mean?
Vitelliform macular dystrophy is an inherited eye disorder that can cause progressive vision loss. It causes build-up of fatty yellow pigment (lipofuscin) in the macular area. This, in turn, can damage the light sensitive cells responsible for clear central vision.
Is fundus Flavimaculatus hereditary?
Fundus Flavimaculatus is a genetic condition which is considered to represent one of two ends of the spectrum of a disease which is comprised of the presentation of retinal flecks. Research has shown that the ABCA4 and PRPH2 genes may be linked to the onset of the condition, as well as the overproduction of vitamin A.
Can Stargardts be cured?
There is Currently No Cure for Stargardt Disease Stargardt disease affects the eye’s retina, which is a light-sensitive layer of tissue lining the interior of the back of the eye.
What is eye fundus?
The fundus is the inside, back surface of the eye. It is made up of the retina, macula, optic disc, fovea and blood vessels. With fundus photography, a special fundus camera points through the pupil to the back of the eye and takes pictures. These pictures help your eye doctor to find, watch and treat disease.
Does Vitelliform cause blindness?
Adult-onset vitelliform macular dystrophy presents between 40-60 years. It generally causes mild vision loss that worsens slowly over time.
What is flecked retina?
“Flecked retina” describes disorders characterized by multiple yellow-white retinal lesions of various size and configuration.1,2 A number of inherited or acquired conditions, associated with a variable degree of retinal dysfunction, correspond to this definition.
Does fundus flavimaculatus cause retinal changes in siblings?
Fundus flavimaculatus: polymorphic retinal change in siblings. Y Isashikiand N Ohba Copyright and License information ► Copyright notice This article has been cited byother articles in PMC.
What is fundus flavimaculatus (FFM)?
On the other end of the spectrum is fundus flavimaculatus (FFM) which is similar to Stargardt disease. However, in comparison, tends to have a slow progression rate and a later period of onset.
How is fundus flavimaculatus diagnosed in Stargardt disease?
Some patients have good central vision with minimal or no macular involvement at presentation, and may be diagnosed as fundus flavimaculatus. 8 Stargardt’s disease and fundus flavimaculatus are parts of the phenotypic spectrum of the same disorder and the same genetic etiology is frequently observed.