What increases LDL particle size?

What increases LDL particle size?

Levels of small, dense LDL particles are closely correlated with carbohydrate intake. Fructose increases levels of small, dense LDL particles more than glucose does. Saturated fat increases levels of HDL cholesterol.

Is LDL pattern A bad?

Although high levels of small, dense LDL can increase your risk of heart disease, its ability to cause heart disease independently of other factors (such as diabetes and high trans fat intake) has not been fully established.

Does size of LDL matter?

The LDL size is also important. When both the LDL-P and the LDL size are abnormal, the risk is compounded. The smaller the LDL particle size, the greater the risk. The small LDL particle size allows it to penetrate the vascular endothelium and deposit into the subendothelial layer.

What causes small dense LDL particles?

There is a genetic pre-disposition to have small dense LDL. An atherogenic lifestyle involving minimal activity or exercise along with a typical American diet high in saturated fat is another cause. Insulin resistance or pre-diabetes is the last major cause of small dense LDL.

Can you change LDL particle size?

For patients with small LDL particles, lifestyle and diet changes and/or medication can help change those small particles to larger, safer particles. According to Dr. Agatston, fibrates—which are used to decrease triglycerides and increase HDL—can also increase LDL particle size.

How do you reduce small dense LDL particles?

Can I reduce my amount of small, dense LDLs?

1. Eat a diet very rich in soluble fiber (BYOBB) – Beans, Yams, Oats, Barley, and Berries.
2. Eat fewer refined carbohydrates.
3. Eat much less saturated and trans fats and cholesterol.
4. Exercise regularly, and.
5. Lose excess weight.

How do I change my LDL pattern?

Diets that are low in saturated fat and cholesterol, regular aerobic exercise, and loss of excess body fat have been determined to decrease the number of small LDL particles and increase the number of large LDL particles in the blood. In other words, lifestyle modifications can change pattern B to pattern A.

What does LDL pattern mean?

“LDL pattern B” simply means that you have a substantial proportion of low-density lipoprotein (LDL) particles (often wrongly called “LDL cholesterol”) that are abnormally small. The contents of the two LDL particles also differ, with smaller LDL particles having greater triglyceride content and less cholesterol.

How do I raise my LDL B pattern?

For patients who started out with the pattern B cholesterol profile, the study by Krauss and his research group showed that an extreme low-fat/high-carbohydrate diet can reduce the number of circulating small LDL particles which in turn reduces the risk of heart disease.

What are LDL cholesterol particle size patterns a and B?

What are LDL cholesterol particle size patterns A and B? The LDL patterns A and B refer to the size of LDL cholesterol particles in the blood. Some doctors believe that small LDL cholesterol particles in the blood may pose a greater risk for developing atherosclerosis and heart attacks than the absolute level of LDL cholesterol in the blood.

Which is the best pattern for LDL cholesterol?

Phenotype or Pattern A – Predominant LDL species is large. This is the one you want! Phenotype or Pattern B (not to be confused with apoB) – Predominant LDL species is small 3,4 Small, dense LDL (sdLDL), or more accurately small, dense LDL-cholesterol (sdLDL-C), is the cholesterol mass trafficked within the small LDL particles.

What is small dense LDL (sdLDL)?

Small, dense LDL (sdLDL), or more accurately small, dense LDL-cholesterol (sdLDL-C), is the cholesterol mass trafficked within the small LDL particles. It takes 40-70% more smaller LDLs than larger ones to traffic a given cholesterol mass, hence increased sdLDL-C is usually associated with high numbers of small LDL particles and total LDL-P. 5

Why not test for LDL particle size?

The LDL subclass pattern characterized by a preponderance of small, dense LDL particles was significantly associated with a threefold increased risk of myocardial infarction, independent of age, sex, and relative weight. So why not test for LDL particle size? The tests are more expensive! However, there is an answer.