What does mCPBA reagent do?
mCPBA is widely used for chemical transformations such as the oxidation of carbonyl compounds, iminoindolines, olefins, imines, alkanes, silyl enol ethers, N- and S-heterocycles, active methylene groups, fluoromethylated allylic bromides, cyclic acetals, N-substituted phthalimidines, selenides, furans and phosphates.
Is mCPBA corrosive?
A white solid, it is used widely as an oxidant in organic synthesis. mCPBA is often preferred to other peroxy acids because of its relative ease of handling. mCPBA is a strong oxidizing agent that may cause fire upon contact with flammable material….meta-Chloroperoxybenzoic acid.
| Names | |
|---|---|
| Signal word | Danger |
| Hazard statements | H226 , H314 , H335 |
Is mCPBA toxic?
3-Chloroperbenzoic acid (MCPBA) is a strong oxidizing agent that may cause a fire upon contact with heat and other flammable materials. It may be harmful if ingested, inhaled, or absorbed through the skin. It causes irritation to the gastrointestinal tract, respiratory tract, skin, and eyes.
Why is commercial mCPBA often less than 75 pure and what are the impurities?
Advantages of 3-chloroperbenzoic acid is its handling, because it is present as powder, which can be kept in the refrigerator. Nevertheless, material of purity >75% is rarely available commercially, since the pure compound is not particularly stable.
Is mCPBA soluble in water?
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| BIOLOGICAL INFO | |
|---|---|
| Solubility: | Insoluble in water; Soluble in KOH, chloroform and acetone |
How do you quench mCPBA?
Simply add acetone. By product is methylacetate.
What is the structure of mCPBA?
C7H5ClO3meta-Chloroperoxybenzoic acid / Formula
What is mCPBA to ketones?
Peroxycarboxylic acids, such as meta-chloroperoxybenzoic acid (mCPBA), are capable of oxidizing ketones to esters in a reaction known as the Baeyer-Villiger oxidation.
What happens when acetophenone is treated with mCPBA?
When an acetophenone is treated with a peracid (e.g. mCPBA), two distinct oxidation mechanisms can take place: (1) the direct hydroxylation of the benzene ring as previously described in an account from our laboratory,9 a mechanism that we believe involves a direct HO+ transfer from peracid [R–C(=O)OOH] to the benzene …
Is mCPBA a strong oxidizing agent?
3-Chloroperoxybenzoic acid, MCPBA, meta-Chloroperbenzoic acid. MCPBA is a strong oxidizing agent, which is comparable with other peracids. Advantages of 3-chloroperbenzoic acid is its handling, because it is present as powder, which can be kept in the refrigerator.
What is the molecular weight of mCPBA?
MCPBA Common Name MCPBA MCPBA MCPBA CAS Number 937-14-4 Molecular Weight 172.566 Density 1.4±0.1 g/cm3 Boiling Point 305.5±44.0 °C at 760 mmHg Molecular Formula C 7 H 5 ClO 3 Melting Point 69-71 °C (lit.) MSDS N/A Flash Point 138.6±28.4 °C
What is 3-chloroperbenzoic acid (mCPBA)?
MCPBA is a strong oxidizing agent, which is comparable with other peracids. Advantages of 3-chloroperbenzoic acid is its handling, because it is present as powder, which can be kept in the refrigerator. Nevertheless, material of purity >75% is rarely available commercially, since the pure compound is not particularly stable.
Why is mCPBA used to synthesize phenols?
The use of MCPBA achieves a mild and highly efficient synthesis of phenols from arylboronic acids in a aqueous solution at room temperature. Isotopical labeling studies show that the hydroxyl oxygen atom of the phenol might originate from the MCPBA. D.-S. Chen, J.-M. Huang, Synlett, 2013, 24, 499-501.