What does elevated beta 2 globulin mean?

What does elevated beta 2 globulin mean?

High levels of B2M in cerebrospinal fluid can mean that cancer has spread to the brain and/or spinal cord.

What does beta-2 microglobulin indicate?

A small protein normally found on the surface of many cells, including lymphocytes, and in small amounts in the blood and urine. An increased amount in the blood or urine may be a sign of certain diseases, including some types of cancer, such as multiple myeloma or lymphoma.

Why is my beta globulin high?

High levels may indicate infection, inflammatory disease or immune disorders. High globulin levels may also indicate certain types of cancer, such as multiple myeloma, Hodgkin’s disease, or malignant lymphoma.

What is beta-2 microglobulin amyloidosis?

Beta-2 ̶ microglobulin (beta-2m) amyloidosis is a disabling condition that affects patients undergoing long-term hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD). Case reports involving patients with near ̶ end-stage renal disease also exist.

Is beta-2 microglobulin the same as beta globulin?

Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electrically charged solutions than gamma globulins, but less mobile than alpha globulins. Examples of beta globulins include: beta-2 microglobulin.

What does a globulin level of 4.0 mean?

The normal range of globulin is around 2.0-3.9 g/dL or 20-39 g/L. Some lab-to-lab variability occurs due to differences in equipment, techniques, and chemicals used. Globulin in the normal range usually implies a normal balance of carrier proteins, enzymes, and antibodies that are needed for many biological processes.

How does amyloidosis affect the kidneys?

Amyloid can harm the kidneys’ filtering system, causing protein to leak from your blood into your urine. The kidneys’ ability to remove waste products from your body is lowered, which may eventually lead to kidney failure and the need for dialysis.

What is amyloidosis and what causes it?

In general, amyloidosis is caused by the buildup of an abnormal protein called amyloid. Amyloid is produced in your bone marrow and can be deposited in any tissue or organ. The specific cause of your condition depends on the type of amyloidosis you have.

How high is globulin in multiple myeloma?

All L.C MM patients had high α2 globulin concentration and normal A/G ratio; 58.3% of this group had hypoproteinemia, 41.7% were normal, in 80% there was no M-spike. In majority of the cases (70%), the plasma cell was >10%. In 12% of cases, it was more than 50% (Figure ​

What is a concerning globulin level?

What is beta-2 microglobulin test used for?

Beta-2 microglobulin blood test is used as a tumor marker for some people with blood cell cancers. Beta-2 microglobulin serum test is not diagnostic for a specific disease, but it has been associated with the amount of cancer present (tumor burden) and can give a healthcare practitioner additional information about someone’s likely prognosis.

What is beta2-microglobulin and why is it important in multiple myeloma?

Multiple myeloma is a cancer of a certain kind of white blood cell, called a plasma cell. At the time of diagnosis, the Beta2-microglobulin levels reflect how advanced the disease is and the likely prognosis for that person. Because Beta-2 Microglobulin is increased with blood cell cancers, it may be useful as a tumor marker.

What does a low beta 2 microglobulin level mean?

Low levels of beta 2 microglobulin are considered normal. Beta 2 microglobulin may be undetectable in the urine and cerebrospinal fluid (CSF). Beta-2 microglobulin blood test is used as a tumor marker for some people with blood cell cancers.

What is a B2M tumor marker test?

A beta-2 microglobulin (B2M) tumor marker test measures the amount of B2M in the blood, urine, or cerebrospinal fluid. It’s most often used to find out how serious your cancer is and how it may develop in the future.