What does Acantholysis mean?
Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders.
What symptom is characteristic of Acantholytic pemphigus?
Skin, Autoimmune Diseases The pemphigus group of autoimmune bullous dermatoses is characterized by loss of adhesion of epidermal keratinocytes (acantholysis). As a result, there is intraepidermal blister formation.
What is Suprabasilar Acantholysis?
Suprabasal acantholysis, a common feature of several inflammatory skin diseases, develops exclusively within the germinative cellular pool of the epidermis. The process induces repair mechanisms by proliferation of cells in the suprabasal layers in whatever conditions it occurs, except in pemphigus vulgaris.
What causes pemphigus Vegetans?
What causes pemphigus? Pemphigus is an autoimmune disorder. With an autoimmune condition, proteins in your immune system called antibodies attack your body’s own cells. The particular autoimmune reaction involved with pemphigus causes blisters.
What is Acantholysis in pemphigus vulgaris?
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, seen in diseases such as pemphigus vulgaris. It is absent in bullous pemphigoid, making it useful for differential diagnosis.
What is focal Acantholysis?
Focal acantholytic dyskeratosis (FAD) is a distinctive histologic pattern characterized by suprabasilar clefts surrounding dermal papillae (villi), acantholytic and dyskeratotic cells at all levels of the epidermis, hyperkeratosis, and parakeratosis.
What is acantholysis in pemphigus vulgaris?
Is Desmoglein a cadherin?
Desmoglein (Dsg) is a cadherin-like adhesion molecule that functions to maintain tissue integrity and facilitates cell–cell communication.