What causes elevated monocytes?
An infection by a bacteria, virus or fungus can cause an increase in monocyte levels. This is because the body creates more monocytes to fight the invader. An absolute monocytes high can also be a response to stress, chronic infections or autoimmune disorders.
What are CD14+ monocytes?
Monocytes are characterized by their phenotypic expression of CD14, and thus, are commonly called CD14+ monocytes. They play an important role in host defense as circulating monocytes and differentiation into tissue macrophages, and can differentiate into dendritic cells with potent antigen-presenting capability.
What does it mean if your monocytes are low?
A low number of monocytes (monocytopenia) can be caused by anything that decreases the overall white blood cell count, such as bloodstream infection, chemotherapy, or a bone marrow disorder. It’s important to speak with your doctor about what this means and what recommendations he has for you based on your results.
What are inflammatory monocytes?
Inflammatory monocytes are the major cellular component in atherosclerotic plaque [47]. Accumulation of activated immune cells, including inflammatory monocytes and macrophages, and T lymphocytes in the vessel wall produce inflammatory cytokines and facilitate vascular inflammation.
Should I be worried if my monocytes are high?
Monocytes and other kinds of white blood cells are necessary to help the body fight disease and infection. Low levels can result from certain medical treatments or bone marrow problems, while high levels can indicate the presence of chronic infections or an autoimmune disease.
What are the symptoms of high monocytes?
Having too many monocytes also causes many of the symptoms of CMML. These monocytes can settle in the spleen or liver, enlarging these organs. An enlarged spleen (called splenomegaly) can cause pain in the upper left part of the belly (abdomen). It can also cause people to notice they feel full too fast when they eat.
What is considered high for monocytes?
Monocytosis or a monocyte count higher than 800/µL in adults indicates that the body is fighting an infection. Monocytosis or a monocyte count higher than 800/µL in adults indicates that the body is fighting an infection.
What is the normal monocyte count?
What is a normal range for my monocyte count? A normal monocyte count is between 2% and 8% of your white blood cell count. This equals about 200 to 800 monocytes per microliter of blood in healthy adults.
Should I be worried if my monocytes are low?
Low or high numbers of monocytes do not usually cause symptoms. However, people may have symptoms of the disorder that caused the change in monocyte number. Diagnosis is by blood testing (complete blood count) done when a person has signs or symptoms of an infection or autoimmune disorder.
Can stress cause low monocytes?
Even though acute stress decreases blood monocyte levels in humans (Brazaitis et al., 2014), it is still unclear whether this is in a subtype-dependent manner.
What type of infections do monocytes fight?
Monocytes are a type of white blood cell. They help fight bacteria, viruses, and other infections in your body.
What infections cause high monocytes?
What Does a High Monocyte Count Mean?
- Endocarditis, a heart valve infection.
- Tuberculosis, a lung infection.
- Syphilis, a sexually transmitted disease.
- Collagen vascular disorders, an inflammation of the collagen and joints.
- Sarcoidosis, an inflammatory disease.
- Protozoan or rickettsial infections.
- Bone marrow recovery.