What are SLCO1B1 drugs?

What are SLCO1B1 drugs?

SLCO1B1 (solute carrier organic anion transporter family member 1B1) is a drug transporter that helps the body get rid of certain medicines through the liver.

What is SLCO1B1 decreased function?

Having SLCO1B1 decreased function means that you may have reduced transport of certain medications into the liver for processing and removal from the body. This may lead to slightly higher than normal medication levels in the body, or have no noticeable effects.

What does OATP1B1 stand for?

OATP1B1

What is SLCO1B1 gene?

The SLCO1B1 gene provides instructions for making a protein called organic anion transporting polypeptide 1B1, or OATP1B1. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body.

Will statin myopathy go away?

While myopathy caused by statins can be mild and can be reversed when the medication is discontinued, it may present as rhabdomyolysis or severe muscle damage.

How do you fix statin muscle damage?

Statins Giving You Achy Muscles? Ask Your Doctor About These 4 Potential Fixes

1. Check for interactions. Sometimes, certain foods or medications prevent the body from eliminating statins at the normal rate, causing statin levels in the body to rise.
2. Try a different statin.
3. Take a lower dose.
4. Try a different option.

What are the nonsynonymous variants of SLCO1B1?

We identified five other nonsynonymous variants in SLCO1B1,including three that were relatively common: rs2306283 (44% frequency of the G allele in controls), rs11045819 (18% frequency of the A allele), and rs34671512 (8% frequency of the C allele) (Table 2a in the Supplementary Appendix).

What does The SLCO1B1 gene do?

Learn more The SLCO1B1 gene provides instructions for making a protein called organic anion transporting polypeptide 1B1, or OATP1B1. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body.

What is the function of OATP1B1?

This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body. For example, the OATP1B1 protein transports bilirubin, which is a yellowish substance that is produced when red blood cells are broken down.

Are SLCO1B1 polymorphisms relevant to other classes of statins?

These findings are likely to apply to other statins because myopathy is a class effect, and SLCO1B1polymorphisms affect the blood levels of several statins. Moreover, these variants may be relevant to the effects of other classes of drugs transported by OATP1B1 (e.g., the oral hypoglycemic agent repaglinide32).