How does dabigatran work in the body?
They work with blood cells called platelets that trigger the clotting process to make sure your blood clots properly. Dabigatran works by stopping a clotting factor called thrombin from working. This thins your blood so it takes longer to clot.
What factors does dabigatran inhibit?
Mechanism of action. Dabigatran is a selective direct competitive thrombin inhibitor that binds to and inhibits both circulating and thrombus-bound thrombin (factor IIa). It produces a rapid onset of predictable anticoagulation.
What is dabigatran etexilate?
Dabigatran etexilate is a prescription medication used to slow and inhibit the formation of blood clots.
Is dabigatran an antiplatelet?
Concomitant antiplatelet drug therapy on top of Dabigatran appeared to increase the risk for major bleeding in AF patients and CHD without affecting the advantages of Dabigatran over Warfarin. It seems that in patients requiring Aspirin 80-100 mg, Dabigatran 110 mg might be a safer alternative to Warfarin.
How does enoxaparin work in the body?
Lovenox (enoxaparin) is an anticoagulant (blood thinner) that works by blocking the activity of certain blood-clotting proteins. As a result, blood clots are less likely to form in your legs, lungs, heart, or other blood vessels.
Is dabigatran a direct thrombin inhibitor?
Dabigatran etexilate: an oral direct thrombin inhibitor for the management of thromboembolic disorders.
What is indication of dabigatran?
PRADAXA is indicated for the treatment of deep venous thrombosis and pulmonary embolism in patients who have been treated with a parenteral anticoagulant for 5-10 days.
Dabigatran etexilate is the only direct thrombin inhibitor clinically available for oral administration. The active compound dabigatran is hardly absorbed from the gastrointestinal tract.
What is the mechanism of action of dabigatran?
Dabigatran is a potent, synthetic, reversible, non-peptide thrombin inhibitor. The inhibition of thrombin results in decreased formation of fibrin and reduces thrombin-stimulated platelet aggregation and thus prevents the formation of thrombi.
Dabigatran is a univalent direct thrombin inhibitor that binds to the active site, thereby inactivating both fibrin-bound and unbound (ie, free) thrombin. 14, 20 Indirect thrombin inhibitors such as unfractionated heparin and low-molecular-weight heparin cannot inhibit fibrin-bound thrombin.
What increases the anticoagulant activity of dabigatran etexilate?
Potassium Iodide may increase the anticoagulant activities of Dabigatran etexilate. Dabigatran etexilate may decrease the excretion rate of Potassium nitrate which could result in a higher serum level. Potassium perchlorate may increase the anticoagulant activities of Dabigatran etexilate.