What is Rip cell?
Abstract. Protein kinases of the receptor interacting protein (RIP) family collaborate with death receptor proteins to regulate cell death.
What does RIP1 stand for?
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
What is a receptor interacting protein?
Introduction. Receptor Interacting Protein (RIP) kinases are a family of Serine/Threonine kinases that play a wide variety of functional roles in cellular signaling during pathogen infection, inflammation, DNA damage, and response to extracellular stimuli. RIP1 is the founding member initially described in 1995.
What does RIPK1 stand for?
Receptor Interacting Serine/Threonine Kinase 1
RIPK1 (Receptor Interacting Serine/Threonine Kinase 1) is a Protein Coding gene. Diseases associated with RIPK1 include Immunodeficiency 57 With Autoinflammation and Autoinflammation With Episodic Fever And Lymphadenopathy. Among its related pathways are Immune response IL-23 signaling pathway and TNFR1 Pathway.
How do you stop necroptosis?
Currently, receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL) have been widely recognized as critical therapeutic targets of the necroptotic machinery. Targeting RIPK1, RIPK3, and/or MLKL is a promising strategy for necroptosis-related diseases.
Are RIP kinases pleiotropic modulators of inflammatory responses?
Receptor-interacting protein (RIP) kinases, in particular RIPK1, RIPK2 and RIPK3, have emerged as pleiotropic modulators of inflammatory responses that act either by directly regulating intracellular inflammatory signaling pathways or by causing apoptotic or necrotic cell death. In this Review, we d …
What is the RIP kinase family?
The RIP kinase family has seven members that share a homologous serine-threonine kinase domain (Fig. 1 ). RIPK1, the ‘founding member’ of the family, was initially identified as a death domain (DD)-containing protein that interacts with the DD of the death receptor CD95 (Fas) 1.
What is the role of RIPK1 and RIPK2?
RIP kinases as modulators of inflammation and immunity. Receptor-interacting protein (RIP) kinases, in particular RIPK1, RIPK2 and RIPK3, have emerged as pleiotropic modulators of inflammatory responses that act either by directly regulating intracellular inflammatory signaling pathways or by causing apoptotic or necrotic cell death.
What is the role of RIP1 kinase in TNF-induced NF-κB?
Kelliher, M. A. et al. The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8, 297–303 (1998). Berger, S. B. et al. Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice. J. Immunol. 192, 5476–5480 (2014).