Is Ribavirin a nucleotide analogue?
Ribavirin, a guanosine nucleoside analog, is a broad-spectrum antiviral that targets a variety of RNA and DNA viruses (Sidwell et al., 1972).
Why are nucleotide or nucleoside analogs effective as drugs?
The nucleoside analogues resemble naturally occurring nucleosides and act by causing termination of the nascent DNA chain. These agents are generally safe and well tolerated as they are used by the viral, but not human polymerases in DNA replication.
What do nucleoside analogs inhibit?
Nucleoside analogs are synthetic, chemically modified nucleosides that mimic their physiological counterparts (endogenous nucleosides) and block cellular division or viral replication by impairment DNA/RNA synthesis or by inhibition of cellular or viral enzymes involved in nucleoside/tide metabolism (Figure 1).
Is Sofosbuvir a nucleoside analogue?
Sofosbuvir (Solvadi, Gilead, Foster City, CA) is a pangenotypic nucleotide analogue NS5B polymerase inhibitor that was approved by the Food and Drug Administration (FDA) in December 2013 for the treatment of HCV genotypes 1, 2, 3, and 4, including those with hepatocellular carcinoma awaiting liver transplant and those …
What class of drug is ribavirin?
Ribavirin is in a class of antiviral medications called nucleoside analogues. It works by stopping the virus that causes hepatitis C from spreading inside the body.
What do nucleotide analogs do?
Nucleotide analogs are nucleotides which contain a nucleic acid analogue, a sugar, and a phosphate groups with one to three phosphates. Nucleoside and nucleotide analogues can be used in therapeutic drugs, include a range of antiviral products used to prevent viral replication in infected cells.
What are structural analogs of nucleotides?
Structurally, nucleotide analogs are acyclic nucleoside phosphonates (nucleoside monophosphates) that are designed to circumvent the first phosphorylation step necessary for the activation of nucleoside analogs, such as zidovudine, stavudine, didanosine, lamivudine, and abacavir (1.
What is the brand name for Remdesivir?
Following the manufacturing and marketing approval from DCGI, Hetero is launching remdesivir under the brand COVIFOR in India.